1. New York: 21,199,865 people
2. Los Angeles: 16,373,645
3. Chicago: 9,157,540
4. Washington: 7,608,070
5. San Francisco: 7,039,362
6. Philadelphia: 6,188,463
7. Boston: 5,819,100
8. Detroit: 5,456,428
9. Dallas: 5,221,801
10. Houston: 4,669,571
11. Atlanta: 4,112,198
12. Miami: 3,876,380
13. Seattle: 3,554,760
14. Phoenix: 3,251,876
15. Minneapolis: 2,968,806

(Source: U.S. Census 2001)